WEBVTT

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Music.

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Your podcast and YouTube blog covering the German startup scene with news,

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interviews, and live events.

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Welcome back, everybody. This is Joe from StartupRate.io, your startup podcast

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and YouTube blog from Germany, Austria, and Switzerland, also known as the Authority

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on GSA, German, Swiss, and Austrian startups.

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Our journey at the Business Angel Day 2024 in the lovely city of Mainz continues.

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In this episode, we'll explore innovative ideas and transformative discussions

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that emerged during this event.

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From key investment trends to breakthrough technologies, get ready to hear firsthand

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from industry leaders and rising stars in the startup scene.

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Don't miss out on this inspiring and innovative episode.

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And please, please keep in mind that is also a live recorded version on site.

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So the interviews were taken on site.

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There may be a little bit background noise, but we did our best to really delete this.

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Happy to get your feedback. Go down here in the show notes and leave us feedback in the feedback form.

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Thank you and have a good day. Hello and welcome to another interview from the

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Business Angel Summit 2024.

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I would like to welcome Thomas Roth from Incipio.

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What specific challenges in surgical planning does Incipio address and who are

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your primary target customers?

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There are more than 6 million surgeries every year that require pre-operative

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surgical planning. Surgical planning is necessary when it comes to designing

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transplants or implants, patients specifically, such as...

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Facial reconstructions after tumor removal that's actually where we are starting,

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we will then scale from head and neck surgery into orthopedics because there's

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many interesting cases there these kinds of surgeries take place in hospitals

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university hospitals rather big hospitals.

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Where they have the capability capabilities of

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treating the patients like that and the decision makers are

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usually the surgeons in the hospitals for the

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better patient treatment um you have one

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example a skull on your on

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your booth could you elaborate a little bit more on

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the specific example what is happening there and how

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your tool helps imagine you

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have a patient that has a bone tumor in the lower jaw or mid face these kind

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of bone tumors have to be removed and the resulting gap in the jaw has to be

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closed of course so that the patient can chew and speak again properly and therefore

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a transplant from the own patient's body is used.

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For example, parts of the pelvic crest, the fibular bone or the scapula.

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And these bones have to be not removed but parts of them and will be taken and

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installed in the facial area to close the defect.

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That's the medical gold standard and we're not changing that.

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We're changing the planning and designing of these transplants.

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Today, this is a very cumbersome and manual process.

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Surgeons have no tools or time to take care of that.

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So today, this is a very outsourced process. They have to outsource the planning

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to engineers out of the clinics, which costs a lot of time, takes a lot of their time.

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Costs a lot of money and leads to delays of several hours in worst cases, in extreme cases.

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And basically, somebody external

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is planning for the surgeon and then the surgeon starts the surgery.

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And then at one point they realize, oh, that was a mistake in planning. Does this happen?

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It might be possible usually they detect misplanning or imperfections before

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that because the surgeons usually check the results of the external engineers before they continue,

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however it still is a pain in the ass for them because if there's any anything

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incorrectly planned they have to set up another video call to discuss the changes

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and tell them what to do differently.

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So again they have to have the second or third web meeting which again takes their time.

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These engineers only work from nine to five and during that time the surgeon

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is in the operating room so they don't really have time for that.

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With our automated solution they can do it whenever they want and wherever they want within seconds.

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Could you elaborate on the current development stage of Incipio and any significant

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milestones achieved to date? Yes of course.

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Incipio is a spin-off of the University Hospital RWTH Aachen.

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That's where the idea was born.

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We have started with an idea and a patent application and what we have achieved

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so far is our patent is granted in the EU and the US for our novel technology.

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We have a very strong prototype that is almost completed and ready for use and

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we are working on the certification of our software as a medical device.

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Our company is already ISO certified

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and we already have a very strong and interdisciplinary team set up.

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We may add Germany is pretty strong in engineering, but your school is one of

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the premier institutions for engineering. That's right.

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What are your current funding status and are you seeking additional investments

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or partnerships to extend your solution?

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Zipio is currently raising 2 million euro and we already have commitments of roughly 1 million.

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We are about to close the financing round in the next couple of weeks and with

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that we will get the market certification entering the market and growing our

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team and what was the rest?

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Partnerships oh yeah and we are always interested in partnerships we are currently

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looking for investments mainly but we are always interested in partnerships

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at its clinics let me start it again,

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we are always looking for partnerships we are well connected

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in the medical world because of our spin-off situation we

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are well connected in germany also switzerland especially but also

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further abroad we're interested in speaking to additional renowned

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surgeons in top hospitals around the world that are

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interested in medical innovation we are

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also interested in partnerships with medical device manufacturers and

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collaboration partners but mainly looking to close

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our fundraising at this point what strategies are you employing to integrate

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into existing surgical workflows and how are you approaching customer acquisition

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we have chosen a very lean setup

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of our technology Surgeons can use our technology in the web browser,

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so it doesn't have to be integrated in the IT systems of the hospital,

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nor does it have to be installed on every computer in the hospital.

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Only a few decision makers and planners in the clinic will use our technology

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and we have the direct connection to them.

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So it's a very smart and easy approach to get installed or get into the hospitals.

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What approach do you use for customer acquisition?

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One of the biggest advantages of Inzipio is that we are the spin-off of the

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University Hospital and our co-founder, Professor Ali Modaba,

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is a key opinion leader and head and neck surgeon.

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So that brings a lot of credibility and we don't have to do cold calls mainly,

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we always get the doors opened through Ali, through our network and that helps

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a lot when reaching out to users in the clinics.

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What KPIs are you monitoring to assess the effectiveness of Incipio and what

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outcomes have you observed so far?

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I'm not sure if this question is relevant because we are pre-revenue, pre-market.

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We have some internal KPIs. Of course, we have some KPIs established in our company.

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For example, we are following an agile development approach in our IT and tech team.

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So, we're doing sprint planning and detailed sprint reviews after two weeks,

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seeing whether our time scheduling and forecasts worked out.

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And we are getting better and better in accuracy and precision.

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And of course, we have some financial KPIs and controlling KPIs that we are following.

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Great. Thank you very much. It was a pleasure talking to you.

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Thank you. It was my pleasure to talk to you. Thank you. It was my pleasure.

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Hello and welcome to another interview from the Mrs. Angel Summit 2024.

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Hi, can you introduce yourself? Hi, my name is Julia and I'm from Carbon Instant.

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What problem does your startup solve and who is your target customer?

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Our startup really solves the question. Today, the concrete industry is quite

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CO2 intensive in their production. So if you produce cement today globally,

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that's about 8% of the global CO2 emissions.

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One of the main problems in terms of climate change. And we work with a negative

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emission technology where we treat this negative emission technology so that

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it can actually be included into,

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for example, concrete.

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Instead of bodies, you're cementing carbon dioxide.

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We are working with Biochar and Biochar is one of the recognized negative emission

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technologies by the IPCC and we developed a patented process where you can actually

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treat the Biochar so that it gains, for example,

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reactivity and is better usable really for the guys in the construction industry.

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And it basically absorbs more carbon dioxide than it produces?

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No, actually, the storing process happens really at the beginning.

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So the process in general, you have CO2 in the air, plants take up the CO2.

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For example, the trees, they grow, they build themselves basically out of carbon

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and release the oxygen back in the air.

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And once, for example, a biomass is not used anymore, for example,

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if a tree is like the leaves are cut, they fall down.

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Usually they degrade or today they get incinerated often.

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And we work with a process called pyrolysis, takes this waste biomass basically

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and basically fixates the carbon in a solid form.

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And this this is a negative emission material and what we do there are a lot

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of really cool people doing this a lot of good plants and plant technologies

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and we are really treating in this carbon so that it can be used in the construction

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way in a in a way that actually has a functional benefit.

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What is your current stage of development and what milestones have you achieved so far?

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So far, we have patented our process.

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We have found partners in the industry to really scale the process,

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the first patent process that we have, and now we're on the verge of scaling the second and third.

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In terms of, you're at the Business Angel Summit, in terms of funding,

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what would you say is your current stage?

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So far we are funded with turnover and grants and we have just got the first

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Business Angel round set up.

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Now we're really looking for partners or Business Angels that

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want to come to us but have

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some additional know-how so we're really looking for

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for business angels from the industry like construction

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industry cement industry anything in that

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direction would be really cool somebody would knowledge in chemistry would also

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be welcome and we do have a couple chemists on board already but if you if you're

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from that area you're always welcome to have a chance in terms of VC terminology

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are we talking about seed or pre seed I'd say we probably,

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kind of in the middle, like with the first product, we are already in the market

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and with the second, we're still a bit in the scaling process and the prototyping.

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What is your go-to-market strategy and how you're acquiring customers or users?

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So, we really have a licensing model so that we are not going to be the people

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really producing the materials.

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It's a lot of great people that can do this already.

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We're really enabling the people along the supply chain to do this. Ah, yes.

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We're really lucky. We have a couple of very good industry partners,

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and of course they themselves are quite well connected.

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And we have some people in team which are really good connected in the construction industry as well.

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What key metrics or KPIs are you tracking and what results have you observed so far?

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So what does your startup have to do better? Yeah.

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For us, really the key is functionality. So for us, to have a solution which

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is really good is really that we can outperform conventional material.

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Do you have any metrics that you can quote here?

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For example, we are always looking at reactivity, we're always looking at,

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of course, the standard things like compressive strength, flexural strength,

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but also metrics which are a bit more delicate,

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like, for example, durability and, of course, CO2 footprint is one of the main things as well.

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Can you give us a rough idea? You're better like two times, five times, 50 times?

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We're still working on this but it looks like we we will probably be a bit better

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than um than the one i can i can tell a bit more once the patent is released next year,

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okay so you cannot tell due to patent restrictions okay thank you very much

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it was a pleasure having you thank you so much i'm bringing you another interview

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from the business angels summit,

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germany 2024 hey can you introduce yourself briefly hi my name is christoph

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grün i'm um CEO of Kavichan.

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We are a spin-off of the Karlsruhe Institute of Technology and we are aiming

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to revolutionize oxygen sensing in 3D cell cultures.

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How do undetected side effects during drug development impact the pharmaceutical

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industry and how does Kevigin aim to address this issue?

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So, if you are looking at the drug development at the moment,

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most of the cell cultures are done under ambient atmosphere,

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so far away from the human conditions. with the results that the results of

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your experience are not direct transferable to the patients.

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So side effects can occur and with every side effect the time to market is longer for the drugs.

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This means for example up to 45 million dollars.

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This can lead to up to 200,000 of deaths due to side effects in Europe alone.

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So this is a high impact that you have good in vitro models for your drug testing.

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What specific challenges in in vitro testing does Kevigen address and who are

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your primary customers?

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So you need a drug development in vitro model that's close to the human body.

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Not only that you have 3D cell cultures, but you need the right oxygen concentration.

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For example, in the heart, you have around 5% of oxygen.

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Current methods are done under ambient atmosphere with around 20% of oxygen.

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So you need to adjust the setting to the human conditions.

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And this can be solved with our products. And you're already holding something

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in your hand. Can you show that? Yeah.

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We are using... Yeah, you can't... Maybe you can't see it. These are micro-cavities.

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They are around 300 micrometers in diameter.

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And these micro cavities are out of an oxygen

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sensitive polymer film we thermoform

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it to these cavities and now you can culture your cells

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in this tiny little micro cavities and measure oxygen in the direct micro environment

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of the cells and with our technology you can get up to 15 000 of micro cavities

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in such a blade which means you can do high throughput experiments and create

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a lot of results on a single plate.

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Could you elaborate on the current development stage of Kevigin and any significant

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milestones achieved to date?

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Well, the last four years we've done our proof of concept of this technology.

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We created first prototypes and now in the seed round we are looking for investment

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to bring the idea from the prototype phase to the market.

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What is your current funding status and are you seeking additional investments or partnerships,

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and at the moment we are funded by the helmholtz association with a funding

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program and we are in a seat financing route and looking for up to 500 000 euros for the first round,

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to bring this idea to market we need investment for sales and for software development.

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What strategies are you employing to integrate Kevigin's technology into existing

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drug development workflows and how are you approaching customer acquisition?

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We can integrate our technology directly in the drug development process because

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you can do your current methods like microscopy as well in our microplates.

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So we add additional information in the ongoing process.

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This means customer can easily integrate our system in the process and in the

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end, with our method, you have one system from the beginning of generating spheres

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and organoids to the end, to the results.

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With our system, you can start by generating the spheres and organoids,

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adjust to a physiological oxygen level, do your experiments under conditions

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that are transferable to humans,

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and also do your ongoing methods like microscopy or other essays,

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and in the end get results that are next level because you have done it under

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physiological conditions.

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What key performance indicators, KPIs, are you monitoring to assess the effectiveness,

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of Kavigen's solution and what outcomes have you observed so far?

00:19:54.724 --> 00:19:59.464
So far we can see that you can significantly reduce your time of experiments

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because, as I mentioned, with one system you can do the whole process from generating

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the cell cultures to the results.

00:20:06.004 --> 00:20:09.384
This is one thing, reducing the time of your experiments.

00:20:09.644 --> 00:20:12.624
And you can also do high-throughput experiments. As I mentioned,

00:20:13.044 --> 00:20:15.924
15,000 spheres on one blade.

00:20:16.084 --> 00:20:18.984
Current systems mostly can do like 100 to 400.

00:20:21.052 --> 00:20:24.152
So you're significantly scaling up the process? You're scaling up the process,

00:20:24.332 --> 00:20:29.372
reducing time, reducing money because you are saving time and you don't need

00:20:29.372 --> 00:20:31.752
so much sales for your experiments.

00:20:32.032 --> 00:20:37.532
You have a higher number of data. You can do more statistics,

00:20:37.912 --> 00:20:40.732
get better results and with a higher impact.

00:20:41.732 --> 00:20:45.832
Do you have a rough idea how much faster the process is with you?

00:20:47.272 --> 00:20:51.452
It's hard to just say in general because it depends on every single process,

00:20:51.612 --> 00:20:53.652
on the application, on your organ type.

00:20:53.872 --> 00:20:55.772
But what we can say is that we

00:20:55.772 --> 00:20:58.952
can provide a solution for different applications because of our process.

00:20:59.132 --> 00:21:03.632
We can adjust the sizes of the micro cavities to the specific need.

00:21:04.292 --> 00:21:09.612
So with this in mind, it's hard to say, okay, we can reduce it five times because

00:21:09.612 --> 00:21:11.172
every process is different.

00:21:11.432 --> 00:21:15.412
And if you're looking for spheres, organites, yeah, you have great difference.

00:21:15.412 --> 00:21:21.092
But with our system, we can cover the whole thing, starting with small spheroids

00:21:21.092 --> 00:21:23.532
up to bigger or larger organoids.

00:21:23.792 --> 00:21:27.312
So, yeah, you have to look at a specific experiment.

00:21:28.172 --> 00:21:33.092
Great. Thank you very much. Welcome. Thank you for the interview. My pleasure.

00:21:37.520 --> 00:22:04.442
Music.

